PDRN vs Centella Asiatica (Cica): Which Is Better for Your Skin?
Compare PDRN and Centella Asiatica (Cica) for skincare. Learn the differences in mechanism, results, and when to use each for optimal skin health.
Quick Comparison
| Mechanism | PDRN: DNA fragment signaling activates adenosine A2A receptors for cellular regeneration Centella Asiatica (Cica): Stimulates collagen synthesis, anti-inflammatory, wound healing |
|---|---|
| Primary Use | PDRN: Skin regeneration, wound healing, anti-aging Centella Asiatica (Cica): Calming, wound healing, barrier repair |
| Molecular Weight | PDRN: 50-1500 kDa (optimized for skin penetration) Centella Asiatica (Cica): Various triterpenes |
| Penetration | PDRN: Injectable or enhanced topical delivery Centella Asiatica (Cica): Moderate |
| Irritation Potential | PDRN: Very Low Centella Asiatica (Cica): Very Low |
How Does Centella Asiatica (Cica) Work?
Centella Asiatica (Cica) is a healing agent that stimulates collagen synthesis, anti-inflammatory, wound healing. It's primarily used for calming, wound healing, barrier repair.
With a molecular weight of Various triterpenes, Centella Asiatica (Cica) has moderate penetration capabilities. The irritation potential is very low, making it suitable for most skin types.
How Does PDRN Compare?
PDRN (Polydeoxyribonucleotide) works through a fundamentally different mechanism. Derived from salmon DNA, PDRN provides nucleotide fragments that activate the adenosine A2A receptor pathway, triggering genuine cellular regeneration and tissue repair.
PDRN works at DNA level, cica works at protein/matrix level
Centella Asiatica (Cica) Best For
- Sensitive skin
- Post-procedure
- Irritated skin
Centella Asiatica (Cica) Not Ideal For
- Rare allergies to Apiaceae family
Can You Use PDRN and Centella Asiatica (Cica) Together?
Both target tissue repair - synergistic healing
The Verdict
Excellent combination for accelerated healing
Frequently Asked Questions
What is the main difference between PDRN and Centella Asiatica (Cica)?
PDRN works through DNA fragment signaling to activate cellular repair and regeneration at a fundamental level. Centella Asiatica (Cica) stimulates collagen synthesis, anti-inflammatory, wound healing. While both can benefit skin health, they work through completely different pathways.
Can I use PDRN and Centella Asiatica (Cica) in the same routine?
Both target tissue repair - synergistic healing
Which is better for anti-aging: PDRN or Centella Asiatica (Cica)?
PDRN works at DNA level, cica works at protein/matrix level Excellent combination for accelerated healing
Is PDRN or Centella Asiatica (Cica) more irritating?
PDRN has very low irritation potential and is well-tolerated by most skin types. Centella Asiatica (Cica) has very low irritation potential. Both are generally well-tolerated.