PDRN vs Fraxel Laser: Which Is Better for Your Skin?
Compare PDRN and Fraxel Laser for skincare. Learn the differences in mechanism, results, and when to use each for optimal skin health.
Quick Comparison
| Mechanism | PDRN: DNA fragment signaling activates adenosine A2A receptors for cellular regeneration Fraxel Laser: Original fractional laser technology |
|---|---|
| Primary Use | PDRN: Skin regeneration, wound healing, anti-aging Fraxel Laser: Scars, wrinkles, pigmentation |
| Molecular Weight | PDRN: 50-1500 kDa (optimized for skin penetration) Fraxel Laser: N/A - device |
| Penetration | PDRN: Injectable or enhanced topical delivery Fraxel Laser: Fractional columns |
| Irritation Potential | PDRN: Very Low Fraxel Laser: Moderate to High |
How Does Fraxel Laser Work?
Fraxel Laser is a professional treatment that original fractional laser technology. It's primarily used for scars, wrinkles, pigmentation.
With a molecular weight of N/A - device, Fraxel Laser has fractional columns penetration capabilities. The irritation potential is moderate to high, making it best suited for those who can tolerate active ingredients.
How Does PDRN Compare?
PDRN (Polydeoxyribonucleotide) works through a fundamentally different mechanism. Derived from salmon DNA, PDRN provides nucleotide fragments that activate the adenosine A2A receptor pathway, triggering genuine cellular regeneration and tissue repair.
Faster healing, better results
Fraxel Laser Best For
- Scars
- Melasma
- Resurfacing
Fraxel Laser Not Ideal For
- Dark skin
- Isotretinoin use
Can You Use PDRN and Fraxel Laser Together?
Fraxel + PDRN recovery protocol
The Verdict
Gold standard laser + PDRN
Frequently Asked Questions
What is the main difference between PDRN and Fraxel Laser?
PDRN works through DNA fragment signaling to activate cellular repair and regeneration at a fundamental level. Fraxel Laser original fractional laser technology. While both can benefit skin health, they work through completely different pathways.
Can I use PDRN and Fraxel Laser in the same routine?
Fraxel + PDRN recovery protocol
Which is better for anti-aging: PDRN or Fraxel Laser?
Faster healing, better results Gold standard laser + PDRN
Is PDRN or Fraxel Laser more irritating?
PDRN has very low irritation potential and is well-tolerated by most skin types. Fraxel Laser has moderate to high irritation potential. Consider your skin sensitivity when choosing between them.