PDRN vs Glycine: Which Is Better for Your Skin?
Compare PDRN and Glycine for skincare. Learn the differences in mechanism, results, and when to use each for optimal skin health.
Quick Comparison
| Mechanism | PDRN: DNA fragment signaling activates adenosine A2A receptors for cellular regeneration Glycine: Most abundant amino acid in collagen |
|---|---|
| Primary Use | PDRN: Skin regeneration, wound healing, anti-aging Glycine: Collagen support, wound healing |
| Molecular Weight | PDRN: 50-1500 kDa (optimized for skin penetration) Glycine: 75.1 Da |
| Penetration | PDRN: Injectable or enhanced topical delivery Glycine: Excellent |
| Irritation Potential | PDRN: Very Low Glycine: None |
How Does Glycine Work?
Glycine is a collagen component that most abundant amino acid in collagen. It's primarily used for collagen support, wound healing.
With a molecular weight of 75.1 Da, Glycine has excellent penetration capabilities. The irritation potential is none, making it suitable for most skin types.
How Does PDRN Compare?
PDRN (Polydeoxyribonucleotide) works through a fundamentally different mechanism. Derived from salmon DNA, PDRN provides nucleotide fragments that activate the adenosine A2A receptor pathway, triggering genuine cellular regeneration and tissue repair.
Fundamental repair support
Glycine Best For
- All skin types
- Collagen needs
Glycine Not Ideal For
- None
Can You Use PDRN and Glycine Together?
Primary collagen amino acid + PDRN
The Verdict
Essential amino acid pairing
Frequently Asked Questions
What is the main difference between PDRN and Glycine?
PDRN works through DNA fragment signaling to activate cellular repair and regeneration at a fundamental level. Glycine most abundant amino acid in collagen. While both can benefit skin health, they work through completely different pathways.
Can I use PDRN and Glycine in the same routine?
Primary collagen amino acid + PDRN
Which is better for anti-aging: PDRN or Glycine?
Fundamental repair support Essential amino acid pairing
Is PDRN or Glycine more irritating?
PDRN has very low irritation potential and is well-tolerated by most skin types. Glycine has none irritation potential. Both are generally well-tolerated.