PDRN vs Glycolic Acid (AHA): Which Is Better for Your Skin?
Compare PDRN and Glycolic Acid (AHA) for skincare. Learn the differences in mechanism, results, and when to use each for optimal skin health.
Quick Comparison
| Mechanism | PDRN: DNA fragment signaling activates adenosine A2A receptors for cellular regeneration Glycolic Acid (AHA): Smallest AHA - dissolves bonds between dead skin cells |
|---|---|
| Primary Use | PDRN: Skin regeneration, wound healing, anti-aging Glycolic Acid (AHA): Surface exfoliation, texture improvement, brightening |
| Molecular Weight | PDRN: 50-1500 kDa (optimized for skin penetration) Glycolic Acid (AHA): 76.1 Da |
| Penetration | PDRN: Injectable or enhanced topical delivery Glycolic Acid (AHA): High due to small size |
| Irritation Potential | PDRN: Very Low Glycolic Acid (AHA): Moderate to High |
How Does Glycolic Acid (AHA) Work?
Glycolic Acid (AHA) is a exfoliant that smallest aha - dissolves bonds between dead skin cells. It's primarily used for surface exfoliation, texture improvement, brightening.
With a molecular weight of 76.1 Da, Glycolic Acid (AHA) has high due to small size penetration capabilities. The irritation potential is moderate to high, making it best suited for those who can tolerate active ingredients.
How Does PDRN Compare?
PDRN (Polydeoxyribonucleotide) works through a fundamentally different mechanism. Derived from salmon DNA, PDRN provides nucleotide fragments that activate the adenosine A2A receptor pathway, triggering genuine cellular regeneration and tissue repair.
PDRN supports faster recovery between exfoliation sessions
Glycolic Acid (AHA) Best For
- Dull skin
- Hyperpigmentation
- Fine lines
Glycolic Acid (AHA) Not Ideal For
- Sensitive skin
- Active breakouts
Can You Use PDRN and Glycolic Acid (AHA) Together?
PDRN helps repair barrier disruption from glycolic use
The Verdict
Use glycolic at night, PDRN in morning for recovery
Frequently Asked Questions
What is the main difference between PDRN and Glycolic Acid (AHA)?
PDRN works through DNA fragment signaling to activate cellular repair and regeneration at a fundamental level. Glycolic Acid (AHA) smallest aha - dissolves bonds between dead skin cells. While both can benefit skin health, they work through completely different pathways.
Can I use PDRN and Glycolic Acid (AHA) in the same routine?
PDRN helps repair barrier disruption from glycolic use
Which is better for anti-aging: PDRN or Glycolic Acid (AHA)?
PDRN supports faster recovery between exfoliation sessions Use glycolic at night, PDRN in morning for recovery
Is PDRN or Glycolic Acid (AHA) more irritating?
PDRN has very low irritation potential and is well-tolerated by most skin types. Glycolic Acid (AHA) has moderate to high irritation potential. Consider your skin sensitivity when choosing between them.