PDRN vs Gotu Kola (Centella without Cica branding): Which Is Better for Your Skin?
Compare PDRN and Gotu Kola (Centella without Cica branding) for skincare. Learn the differences in mechanism, results, and when to use each for optimal skin health.
Quick Comparison
| Mechanism | PDRN: DNA fragment signaling activates adenosine A2A receptors for cellular regeneration Gotu Kola (Centella without Cica branding): Same as Centella - wound healing triterpenes |
|---|---|
| Primary Use | PDRN: Skin regeneration, wound healing, anti-aging Gotu Kola (Centella without Cica branding): Wound healing, collagen support |
| Molecular Weight | PDRN: 50-1500 kDa (optimized for skin penetration) Gotu Kola (Centella without Cica branding): Various triterpenes |
| Penetration | PDRN: Injectable or enhanced topical delivery Gotu Kola (Centella without Cica branding): Moderate |
| Irritation Potential | PDRN: Very Low Gotu Kola (Centella without Cica branding): Very Low |
How Does Gotu Kola (Centella without Cica branding) Work?
Gotu Kola (Centella without Cica branding) is a healing agent that same as centella - wound healing triterpenes. It's primarily used for wound healing, collagen support.
With a molecular weight of Various triterpenes, Gotu Kola (Centella without Cica branding) has moderate penetration capabilities. The irritation potential is very low, making it suitable for most skin types.
How Does PDRN Compare?
PDRN (Polydeoxyribonucleotide) works through a fundamentally different mechanism. Derived from salmon DNA, PDRN provides nucleotide fragments that activate the adenosine A2A receptor pathway, triggering genuine cellular regeneration and tissue repair.
Enhanced tissue regeneration
Gotu Kola (Centella without Cica branding) Best For
- Scars
- Wounds
- Stretch marks
Gotu Kola (Centella without Cica branding) Not Ideal For
- Rare allergies
Can You Use PDRN and Gotu Kola (Centella without Cica branding) Together?
Classic healing botanical with PDRN
The Verdict
Traditional healing synergy
Frequently Asked Questions
What is the main difference between PDRN and Gotu Kola (Centella without Cica branding)?
PDRN works through DNA fragment signaling to activate cellular repair and regeneration at a fundamental level. Gotu Kola (Centella without Cica branding) same as centella - wound healing triterpenes. While both can benefit skin health, they work through completely different pathways.
Can I use PDRN and Gotu Kola (Centella without Cica branding) in the same routine?
Classic healing botanical with PDRN
Which is better for anti-aging: PDRN or Gotu Kola (Centella without Cica branding)?
Enhanced tissue regeneration Traditional healing synergy
Is PDRN or Gotu Kola (Centella without Cica branding) more irritating?
PDRN has very low irritation potential and is well-tolerated by most skin types. Gotu Kola (Centella without Cica branding) has very low irritation potential. Both are generally well-tolerated.