PDRN vs Lactic Acid (AHA): Which Is Better for Your Skin?
Compare PDRN and Lactic Acid (AHA) for skincare. Learn the differences in mechanism, results, and when to use each for optimal skin health.
Quick Comparison
| Mechanism | PDRN: DNA fragment signaling activates adenosine A2A receptors for cellular regeneration Lactic Acid (AHA): Gentle AHA that also provides hydration while exfoliating |
|---|---|
| Primary Use | PDRN: Skin regeneration, wound healing, anti-aging Lactic Acid (AHA): Gentle exfoliation, hydration, brightening |
| Molecular Weight | PDRN: 50-1500 kDa (optimized for skin penetration) Lactic Acid (AHA): 90.1 Da |
| Penetration | PDRN: Injectable or enhanced topical delivery Lactic Acid (AHA): Moderate - gentler than glycolic |
| Irritation Potential | PDRN: Very Low Lactic Acid (AHA): Low to Moderate |
How Does Lactic Acid (AHA) Work?
Lactic Acid (AHA) is a exfoliant that gentle aha that also provides hydration while exfoliating. It's primarily used for gentle exfoliation, hydration, brightening.
With a molecular weight of 90.1 Da, Lactic Acid (AHA) has moderate - gentler than glycolic penetration capabilities. The irritation potential is low to moderate, making it best suited for those who can tolerate active ingredients.
How Does PDRN Compare?
PDRN (Polydeoxyribonucleotide) works through a fundamentally different mechanism. Derived from salmon DNA, PDRN provides nucleotide fragments that activate the adenosine A2A receptor pathway, triggering genuine cellular regeneration and tissue repair.
PDRN enhances the hydrating benefits of lactic acid
Lactic Acid (AHA) Best For
- Sensitive skin
- Dry skin
- Beginners
Lactic Acid (AHA) Not Ideal For
- Very sensitive or reactive skin
Can You Use PDRN and Lactic Acid (AHA) Together?
Gentler combination than glycolic - can use closer together
The Verdict
Good pairing for sensitive skin types
Frequently Asked Questions
What is the main difference between PDRN and Lactic Acid (AHA)?
PDRN works through DNA fragment signaling to activate cellular repair and regeneration at a fundamental level. Lactic Acid (AHA) gentle aha that also provides hydration while exfoliating. While both can benefit skin health, they work through completely different pathways.
Can I use PDRN and Lactic Acid (AHA) in the same routine?
Gentler combination than glycolic - can use closer together
Which is better for anti-aging: PDRN or Lactic Acid (AHA)?
PDRN enhances the hydrating benefits of lactic acid Good pairing for sensitive skin types
Is PDRN or Lactic Acid (AHA) more irritating?
PDRN has very low irritation potential and is well-tolerated by most skin types. Lactic Acid (AHA) has low to moderate irritation potential. Consider your skin sensitivity when choosing between them.