PDRN vs LHA (Lipohydroxy Acid): Which Is Better for Your Skin?
Compare PDRN and LHA (Lipohydroxy Acid) for skincare. Learn the differences in mechanism, results, and when to use each for optimal skin health.
Quick Comparison
| Mechanism | PDRN: DNA fragment signaling activates adenosine A2A receptors for cellular regeneration LHA (Lipohydroxy Acid): Fat-soluble salicylic derivative for targeted pore action |
|---|---|
| Primary Use | PDRN: Skin regeneration, wound healing, anti-aging LHA (Lipohydroxy Acid): Pore clarifying, gentle exfoliation |
| Molecular Weight | PDRN: 50-1500 kDa (optimized for skin penetration) LHA (Lipohydroxy Acid): 194 Da |
| Penetration | PDRN: Injectable or enhanced topical delivery LHA (Lipohydroxy Acid): Targeted to pores |
| Irritation Potential | PDRN: Very Low LHA (Lipohydroxy Acid): Low |
How Does LHA (Lipohydroxy Acid) Work?
LHA (Lipohydroxy Acid) is a targeted exfoliant that fat-soluble salicylic derivative for targeted pore action. It's primarily used for pore clarifying, gentle exfoliation.
With a molecular weight of 194 Da, LHA (Lipohydroxy Acid) has targeted to pores penetration capabilities. The irritation potential is low, making it best suited for those who can tolerate active ingredients.
How Does PDRN Compare?
PDRN (Polydeoxyribonucleotide) works through a fundamentally different mechanism. Derived from salmon DNA, PDRN provides nucleotide fragments that activate the adenosine A2A receptor pathway, triggering genuine cellular regeneration and tissue repair.
Clear pores for better absorption
LHA (Lipohydroxy Acid) Best For
- Large pores
- Blackheads
- Sensitive acne-prone
LHA (Lipohydroxy Acid) Not Ideal For
- None significant
Can You Use PDRN and LHA (Lipohydroxy Acid) Together?
Gentle pore prep for PDRN
The Verdict
Refined exfoliation pairing
Frequently Asked Questions
What is the main difference between PDRN and LHA (Lipohydroxy Acid)?
PDRN works through DNA fragment signaling to activate cellular repair and regeneration at a fundamental level. LHA (Lipohydroxy Acid) fat-soluble salicylic derivative for targeted pore action. While both can benefit skin health, they work through completely different pathways.
Can I use PDRN and LHA (Lipohydroxy Acid) in the same routine?
Gentle pore prep for PDRN
Which is better for anti-aging: PDRN or LHA (Lipohydroxy Acid)?
Clear pores for better absorption Refined exfoliation pairing
Is PDRN or LHA (Lipohydroxy Acid) more irritating?
PDRN has very low irritation potential and is well-tolerated by most skin types. LHA (Lipohydroxy Acid) has low irritation potential. Consider your skin sensitivity when choosing between them.