PDRN vs PHAs (Polyhydroxy Acids): Which Is Better for Your Skin?
Compare PDRN and PHAs (Polyhydroxy Acids) for skincare. Learn the differences in mechanism, results, and when to use each for optimal skin health.
Quick Comparison
| Mechanism | PDRN: DNA fragment signaling activates adenosine A2A receptors for cellular regeneration PHAs (Polyhydroxy Acids): Large molecule AHAs that exfoliate without irritation |
|---|---|
| Primary Use | PDRN: Skin regeneration, wound healing, anti-aging PHAs (Polyhydroxy Acids): Gentle exfoliation, hydration, anti-aging |
| Molecular Weight | PDRN: 50-1500 kDa (optimized for skin penetration) PHAs (Polyhydroxy Acids): 178-268 Da |
| Penetration | PDRN: Injectable or enhanced topical delivery PHAs (Polyhydroxy Acids): Surface (gentle) |
| Irritation Potential | PDRN: Very Low PHAs (Polyhydroxy Acids): Very Low |
How Does PHAs (Polyhydroxy Acids) Work?
PHAs (Polyhydroxy Acids) is a exfoliant that large molecule ahas that exfoliate without irritation. It's primarily used for gentle exfoliation, hydration, anti-aging.
With a molecular weight of 178-268 Da, PHAs (Polyhydroxy Acids) has surface (gentle) penetration capabilities. The irritation potential is very low, making it suitable for most skin types.
How Does PDRN Compare?
PDRN (Polydeoxyribonucleotide) works through a fundamentally different mechanism. Derived from salmon DNA, PDRN provides nucleotide fragments that activate the adenosine A2A receptor pathway, triggering genuine cellular regeneration and tissue repair.
Non-irritating exfoliation before PDRN
PHAs (Polyhydroxy Acids) Best For
- Sensitive skin
- Rosacea
- Beginners
PHAs (Polyhydroxy Acids) Not Ideal For
- None significant
Can You Use PDRN and PHAs (Polyhydroxy Acids) Together?
Gentle prep for PDRN without irritation
The Verdict
Ideal exfoliant for PDRN users
Frequently Asked Questions
What is the main difference between PDRN and PHAs (Polyhydroxy Acids)?
PDRN works through DNA fragment signaling to activate cellular repair and regeneration at a fundamental level. PHAs (Polyhydroxy Acids) large molecule ahas that exfoliate without irritation. While both can benefit skin health, they work through completely different pathways.
Can I use PDRN and PHAs (Polyhydroxy Acids) in the same routine?
Gentle prep for PDRN without irritation
Which is better for anti-aging: PDRN or PHAs (Polyhydroxy Acids)?
Non-irritating exfoliation before PDRN Ideal exfoliant for PDRN users
Is PDRN or PHAs (Polyhydroxy Acids) more irritating?
PDRN has very low irritation potential and is well-tolerated by most skin types. PHAs (Polyhydroxy Acids) has very low irritation potential. Both are generally well-tolerated.