PDRN vs Subcision: Which Is Better for Your Skin?
Compare PDRN and Subcision for skincare. Learn the differences in mechanism, results, and when to use each for optimal skin health.
Quick Comparison
| Mechanism | PDRN: DNA fragment signaling activates adenosine A2A receptors for cellular regeneration Subcision: Breaking fibrous bands under scars |
|---|---|
| Primary Use | PDRN: Skin regeneration, wound healing, anti-aging Subcision: Rolling acne scars, tethered scars |
| Molecular Weight | PDRN: 50-1500 kDa (optimized for skin penetration) Subcision: N/A - procedure |
| Penetration | PDRN: Injectable or enhanced topical delivery Subcision: Subcutaneous |
| Irritation Potential | PDRN: Very Low Subcision: Moderate - bruising |
How Does Subcision Work?
Subcision is a professional procedure that breaking fibrous bands under scars. It's primarily used for rolling acne scars, tethered scars.
With a molecular weight of N/A - procedure, Subcision has subcutaneous penetration capabilities. The irritation potential is moderate - bruising, making it best suited for those who can tolerate active ingredients.
How Does PDRN Compare?
PDRN (Polydeoxyribonucleotide) works through a fundamentally different mechanism. Derived from salmon DNA, PDRN provides nucleotide fragments that activate the adenosine A2A receptor pathway, triggering genuine cellular regeneration and tissue repair.
Optimal healing post-subcision
Subcision Best For
- Rolling scars
- Tethered scars
Subcision Not Ideal For
- Keloid history
- Infection
Can You Use PDRN and Subcision Together?
Scar release + PDRN healing
The Verdict
Scar treatment protocol
Frequently Asked Questions
What is the main difference between PDRN and Subcision?
PDRN works through DNA fragment signaling to activate cellular repair and regeneration at a fundamental level. Subcision breaking fibrous bands under scars. While both can benefit skin health, they work through completely different pathways.
Can I use PDRN and Subcision in the same routine?
Scar release + PDRN healing
Which is better for anti-aging: PDRN or Subcision?
Optimal healing post-subcision Scar treatment protocol
Is PDRN or Subcision more irritating?
PDRN has very low irritation potential and is well-tolerated by most skin types. Subcision has moderate - bruising irritation potential. Consider your skin sensitivity when choosing between them.